|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Its core subunit, PD2/hPaf1, is amplified and overexpressed in many cancers.
|
17599057 |
2007 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Taken together, these findings link the tumor suppressor parafibromin to the transcription elongation and RNA processing pathway as a PAF1 complex- and RNA polymerase II-bound protein.
|
15923622 |
2005 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
The new synthesized Pd(II) complexes <b>1</b> and <b>2</b> exhibit an important potential through their selective cytotoxic activity and by targeting the stem-like tumor cell populations, which leads to the tumor growth arrest and prevention of metastasis.
|
28358339 |
2017 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Indeed, Paf1 (also known as PD2 or pancreatic differentiation 2) is found to be upregulated in poorly differentiated cancer cells, and such upregulation is involved in cellular transformation or oncogenesis.
|
29023102 |
2017 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Further, an overexpression of PD2/hPaf1 results in the induction of a transformed phenotype, suggesting its possible involvement in tumorigenesis.
|
17599057 |
2007 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The new synthesized Pd(II) complexes <b>1</b> and <b>2</b> exhibit an important potential through their selective cytotoxic activity and by targeting the stem-like tumor cell populations, which leads to the tumor growth arrest and prevention of metastasis.
|
28358339 |
2017 |
|
Hyperparathyroidism-Jaw Tumor Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The hyperparathyroidism-jaw tumor syndrome (HPT-JT) is a familial cancer syndrome that can result from germline inactivation of HRPT2/CDC73, a putative tumor suppressor gene that encodes parafibromin, a component of the transcriptional regulatory PAF1 complex with homology to the yeast protein Cdc73p.
|
20304979 |
2010 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Levels of PAF1 and FOSL1 were increased in PDAC tissues, especially those from smokers, compared with nontumor pancreatic tissue.
|
29864419 |
2018 |
|
Pancreatic carcinoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
|
22046413 |
2011 |
|
Malignant neoplasm of pancreas
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Human RNA polymerase II-association factor 1 (hPaf1/PD2) regulates histone methylation and chromatin remodeling in pancreatic cancer.
|
22046413 |
2011 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of <i>Hoxa9</i> and <i>Meis1</i> in acute myeloid leukemia.
|
29774127 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The free salen ligand and its Pd(II) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(II) complexes.
|
22858862 |
2012 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The human PAF1 complex is linked to cancer, and in yeast, it has been reported to play a role in telomere biology.
|
29564528 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
We find that Paf1 undergoes ubiquitylation and is degraded by the 26S proteasome in yeast, thus deciphering UPS regulation of an evolutionarily conserved factor, Paf1, involved in various cellular processes at the crossroads of the cancer networks.
|
29023102 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Here, we concisely describe multifaceted roles of PD2/PAF1 associated with oncogenic transformation and implicate PD2/PAF1 as an attractive target for therapeutic development to combat malignancy.<i>Cancer Res; 78(2); 313-9.©2018 AACR</i>.
|
29311159 |
2018 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Our results showed that the Pd(II) complex was more cytotoxic to cancer cells than noncancer cell lines and caused cell death through apoptotic pathways.
|
28657910 |
2017 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
The Pd(II) complexes have been tested for in vitro cytotoxicity activities against cancer cell line of K<sub>562</sub>.
|
28849726 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Here, we concisely describe multifaceted roles of PD2/PAF1 associated with oncogenic transformation and implicate PD2/PAF1 as an attractive target for therapeutic development to combat malignancy.<i>Cancer Res; 78(2); 313-9.©2018 AACR</i>.
|
29311159 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The human PAF1 complex is linked to cancer, and in yeast, it has been reported to play a role in telomere biology.
|
29564528 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
We find that Paf1 undergoes ubiquitylation and is degraded by the 26S proteasome in yeast, thus deciphering UPS regulation of an evolutionarily conserved factor, Paf1, involved in various cellular processes at the crossroads of the cancer networks.
|
29023102 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
Our results showed that the Pd(II) complex was more cytotoxic to cancer cells than noncancer cell lines and caused cell death through apoptotic pathways.
|
28657910 |
2017 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The Pd(II) complexes have been tested for in vitro cytotoxicity activities against cancer cell line of K<sub>562</sub>.
|
28849726 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
Biomarker
|
group |
BEFREE |
The free salen ligand and its Pd(II) complexes have also been tested against human hepatoma cancer cell line (Huh7) and results manifested exceptional anti-proliferative effects of the Pd(II) complexes.
|
22858862 |
2012 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Pt(II) and Pd(II) complexes with a thiazoline derivative ligand: Synthesis, structural characterization, antiproliferative activity and evaluation of pro-apoptotic ability in tumor cell lines HT-29 and U-937.
|
31689624 |
2020 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Our results indicate that hPaf1/PD2 is overexpressed in OCSCs and maintains the self-renewal of OCSCs through its interaction with OCT3/4; thus, hPaf1/PD2 may be a potential therapeutic target to overcome tumor relapse in OC.
|
28122356 |
2017 |